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APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
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DeCS
Descriptor
English
:
Apoptotic Protease-Activating Factor 1
Descriptor
Spanish
:
Factor Apoptótico 1 Activador de Proteasas
Descriptor
Portuguese
:
Fator Apoptótico 1 Ativador de Proteases
Synonyms
English
:
Apaf-1 Protease-Activating Factor
Apoptotic Peptidase Activating Factor 1
Apaf 1 Protease Activating Factor
Apoptotic Protease Activating Factor 1
Protease-Activating Factor, Apaf-1
Tree Number:
D12.644.360.024.131.124
D12.644.360.075.358.124
D12.776.157.057.006.124
D12.776.476.024.139.124
D12.776.476.075.358.124
Definition
English
:
A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal
WD40 REPEATS
. It plays a role in the mitochondria-stimulated
apoptosis
(
APOPTOSIS
, INTRINSIC PATHWAY) and binds to
CYTOCHROME
C in the
CYTOSOL
to form an APOPTOSOMAL PROTEIN COMPLEX which activates
INITIATOR CASPASES
such as
CASPASE 9.
History Note
English
:
2007(1997)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52304
Unique Identifier:
D053477
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS